REVIEW: Circulating Osteoprotegerin and Receptor Activator for Nuclear Factor B Ligand: Clinical Utility in Metabolic Bone Disease Assessment
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چکیده
Context: The discovery of the receptor activator for nuclear factor B (RANK) ligand (RANKL)/RANK signaling pathway has marked a major advance in our understanding of the mechanisms controlling osteoclastogenesis. RANKL, expressed by preosteoblasts and stromal cells, binds to RANK, expressed by cells of the osteoclast lineage, inducing a signaling cascade leading to the differentiation and fusion of osteoclast precursor cells and stimulating the activity of the mature osteoclast. The effects of RANKL are counteracted by osteoprotegerin (OPG), a soluble neutralizing decoy receptor.
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تاریخ انتشار 2005